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Journal of Drug Research of Egypt. 2010; 31 (1): 89-92
in English | IMEMR | ID: emr-110815

ABSTRACT

This study focuses on the decomposition of tenoxicam alone. The raw material's purity, kinetic parameters, thermal behavior and melting characteristics were determined by differential scanning calorimetry and thermogravimetric analysis. TG.DTA and DSC unit using in an inert atmosphere of flowing nitrogen. The compound was subject to temperature ramp after heating rates, 5, 10, 15, 20, 25 from ambient to 800 C. Mass spectrometry was used as adjunctary technique to identify the products of the decomposition reaction. It was observed that tenoxicam decomposed via multistage reaction following melting. The purity was 99.01 +/- 0.16. The thermal decomposition followed first order kinetic, activation energy 87.31 kJ mol and frequency factor of 3.941.I0[7] min[-1]


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal , Differential Thermal Analysis/methods , Thermogravimetry/methods
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